Marley and Me lapped up $36.4 million on approximately 4,400 screens at 3,480 theaters over the weekend, and it broke the Christmas opening day record on Thursday with $14.4 million. Its four-day haul came to $50.7 million, which was a new high for actors Jennifer Aniston and Owen Wilson in lead roles. The picture scored as the most relatable in the market, mixing the type of relationship comedy that powered past hits like Meet the Parents and Parenthood with the antics and sentiment of raising a dog (the popular Labrador retriever breed in this case). In distributor 20th Century Fox's research, families and women were the main demographics.