The 40-piece collection, called One Kiss, is to hit 600 J.C. Penney stores and jcp.com in April. The line features sterling silver, gemstone and diamond designs inspired by a henna symbol that translates to "kiss." The pieces range from layered chains to drop earrings to stackable rings, all retailing for between $79 and $299.

One Kiss is Crawford's second partnership with the $15.1 billion retailer. In April, she signed with Penney's to launch a home and bedding collection, Cindy Crawford Style.

"Once I got 'married' to J.C. Penney, the opportunity to do more just seemed like the right thing to do and jewelry was a fun departure from bedding," Crawford said. "When I started speaking with the jewelry team, we were definitely aware of the success of the Jane Seymour collection for Kay [Jewelers] and her universal symbol of an open heart. But obviously, we can't redo what someone else has done. So we looked for a universal shape that had an appealing aesthetic. We came across this henna symbol for 'kiss,' which I liked. It was cool, but I love what it means. It's not necessarily a romantic kiss, it could be a mother's kiss. You can also buy it for yourself."

The Cindy Crawford Style collection will be on view at Penney's new Manhattan store when it opens in July. Starting in September, the chain's 1,100 locations nationwide will carry a mix of Ms. Crawford's moderately priced tableware, window treatments, furniture and bedding.

Ms. Crawford says the line, like her exercise videos and Meaningful Beauty skin-care brand, is a way to give women a taste of her glamorous lifestyle.

"I've been able to experience amazing things in my life," says the 43-year-old Ms. Crawford. "But I am also just a girl from Illinois with two sisters" -- sisters who, like most people, can't afford private trainers, Parisian facialists and celebrity interior decorators, she says. (Interior designer Michael Smith decorated Ms. Crawford's own homes.)

"I think I look pretty good for 43. But I don't look the way I did when I was 23," says Crawford. "So if Star magazine or whatever wants to print a picture of me on the beach from the back, at the worst possible angle, and say that I have cellulite, I'm like, Guess what? I do, and I never said I didn't.